Anti-terror police sealed off the German city's main train station when the attack happened at around 9pm local time (8pm United Kingdom time).
Two people have been arrested after an "ax rampage" at a major train station left at least four people injured.
As many as five people are reported to have been hurt, although the extent of their injuries is not yet known.
In October, police say they prevented an attack on a Berlin airport by a Syrian refugee, 22-year-old Jaber al-Bakr.
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There were reports of a "crazed man" at the scene and two people were arrested. However so far police have not given any indication as to the motivation or identities of those involved.
Terrified passengers have taken to social media to say the situation inside the station "looks bad". "Stay away from #Dusseldorf train station insane man with #axe on the lose".
The country in on high terror alert following several recent attacks.